Please disable your AV [Antivirus] temporarily while you're doing the extraction of the ES e4.5.1 until you're able to complete the installation.
Include the following folder paths below to your AV [Antivirus] exclusion list once you've got the ES e4.5.1 installed. This way it will not be detected as a threat.
C:\Program Files (x86)\Wilcom
Once the installation process is completed, restart the PC and re-open ES e4.5.1.
Enable your AV [Antivirus] .