If you are referring to the highlighted Red Box and Cross as per below screenshot, this is the point of the centre of the design.
If you do not want this to appear on your design, please utilize the capture design bitmap feature in Outputting designs as images.
Here's how -
https://www.wilcom.com/Help/e4/es/en/downloads/referencemanual.pdf > Outputting designs as images > page 975
Here's the link on how to use Capture design bitmap
Here's the link on how to use Outputting designs as images
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